NS11394
A potent, subtype-selective, orally available GABAA receptor positive modulator with Ki of 0.4, 0.8, 0.5 and 0.1 nM for α1, α2, α3 and α5 subunits together with β3γ2; displays 600 to 2000-fold over GABAA-α4 or GABAA-α6 containing receptors; exhibits in vivo anxiolytic efficacy, attenuates spontaneous nociceptive behaviors in response to hindpaw injection of formalin and capsaicin in rats.
Product Specifications
CAS Number
951650-22-9
Product Name Alternative
NS-11394
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 43 mg/mL
Smiles
N#CC1=CC=CC=C1C2=CC=CC (N3C4=CC=C (C (C) (O) C) C=C4N=C3) =C2
Molecular Formula
C23H19N3O
Molecular Weight
353.4165
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
[1,1'-Biphenyl]-2-carbonitrile, 3'-[5- (1-hydroxy-1-methylethyl) -1H-benzimidazol-1-yl]-
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