A-836339
A-836339 (A836339) is a potent and selective cannabinoid CB2 receptor agonist with Ki of 0.64 and 0.76 nM for human and rat CB2 receptors, displays 425- and 189-fold selectivity over CB1 receptor, respectively; exhibits full agonist efficacy (Emax=102%) with high potency (EC50=1.6 nM), greater potency than other CB2-selective ligands including JWH-015 and GW-842166X; exhibits a potent CB2 receptor-mediated antihyperalgesic effect in various animal pain models, also demonstrates efficacies in the chronic constrain injury (CCI) model of neuropathic pain.
Product Specifications
CAS Number
959746-77-1
Product Name Alternative
A836339
Purity
>98% (HPLC)
Solubility
DMSO: 12 mg/mL
Smiles
CC1=C (C) N (CCOC) /C (S1) =N/C (C2C (C) (C) C2 (C) C) =O
Molecular Formula
C16H26N2O2S
Molecular Weight
310.4548
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cyclopropanecarboxamide, N-[3- (2-methoxyethyl) -4,5-dimethyl-2 (3H) -thiazolylidene]-2,2,3,3-tetramethyl-, [N (Z) ]-
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