ONX-0914
ONX-0914 (PR-957) is a potent, selective inhibitor of the chymotrypsin-like subunit of immunoproteasome LMP7 with IC80 <100 nM, 20- to 40-fold more selective over β5 or LMP2; blocks presentation of LMP7-specific, MHC-I-restricted antigens in vitro and in vivo, blocks production of interleukin-23 (IL-23) by activated monocytes and interferon-gamma and IL-2 by T cells; reverses signs of disease and results in reductions in cellular infiltration, cytokine production and autoantibody levels in experimental arthritis models.
Product Specifications
CAS Number
960374-59-8
Product Name Alternative
PR-957 | ONX 0914 | ONX0914 | PR957 | PR 957
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 35 mg/mL
Smiles
O=C (N[C@@H] (CC1=CC=CC=C1) C ([C@]2 (C) OC2) =O) [C@@H] (NC ([C@@H] (NC (CN3CCOCC3) =O) C) =O) CC4=CC=C (OC) C=C4
Molecular Formula
C31H40N4O7
Molecular Weight
580.6719
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
L-Tyrosinamide, N-[2- (4-morpholinyl) acetyl]-L-alanyl-O-methyl-N-[ (1S) -2-[ (2R) -2-methyl-2-oxiranyl]-2-oxo-1- (phenylmethyl) ethyl]-
Available Sizes
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