Daprodustat
A nove, orally active HIF-prolyl hydroxylase (PHD) inhibitor that stimulate endogenous EPO synthesis and induces effective erythropoiesis by non-EPO effects; shows potential for the treatment of anemia associated with chronic kidney disease.Anemia Phase 3 Clinical (In Vitro) :GSK1278863 is an orally administered small-molecule PHI, and stimulates endogenous EPO synthesis and induce effective erythropoiesis. GSK1278863 has been shown to increase erythropoietin levels, leading to increases in hemoglobin, hematocrit and red blood cell numbers.
Product Specifications
CAS Number
960539-70-2
Product Name Alternative
GSK-1278863 | GSK 1278863
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: < 6.8 mg/mL
Smiles
O=C (O) CNC (C (C (N1C2CCCCC2) =O) C (N (C3CCCCC3) C1=O) =O) =O
Molecular Formula
C19H27N3O6
Molecular Weight
393.4342
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Glycine, N-[ (1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl) carbonyl]-
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