GK921
GK921 is a transglutaminase 2 (TGase 2) inhibitor. GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0.905 μM) . A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI-1 preclinical xenograft tumor models. TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC.
Product Specifications
CAS Number
1025015-40-0
Product Name Alternative
GK921 | GK-921 | GK 921
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL 87.11 mM
Smiles
C1CCN (C1) CCOc1c (nc2c (n1) cccn2) C#Cc1ccccc1
Molecular Formula
C21H20N4O
Molecular Weight
344.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (phenylethynyl) -2- (2- (pyrrolidin-1-yl) ethoxy) pyrido[2,3-b]pyrazine
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