Uprosertib
Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
Product Specifications
CAS Number
1047634-65-0
Product Name Alternative
GSK2141795, GSK 795, Uprosertib
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 150 mg/mL 349.45 mM H2O : < 0.1 mg/mL
Smiles
Cn1c (c (cn1) Cl) c1c (oc (c1) C (=O) N[C@@H] (Cc1cc (c (cc1) F) F) CN) Cl
Molecular Formula
C18H16Cl2F2N4O2
Molecular Weight
429.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- ((S) -1-amino-3- (3,4-difluorophenyl) propan-2-yl) -5-chloro-4- (4-chloro-1-methyl-1H-pyrazol-5-yl) furan-2-carboxamide
Available Sizes
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