AC-264613
AC-264613 is the first agonist of the G-protein-coupled receptor (GPCR) protease activated receptor 2 (PAR2) . AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca (2+) mobilization assays, with potencies ranging from 30 to 100 nM.
Product Specifications
CAS Number
1051487-82-1
Product Name Alternative
AC-264613 | AC 264613 | AC264613
Purity
>98% (HPLC)
Smiles
O=C ([C@H]1C (=O) NC[C@@H]1c1ccccc1) N/N=C (/c1cccc (Br) c1) \C
Molecular Formula
C19H18BrN3O2
Molecular Weight
400.28
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(3R, ?4S) ?-?rel-2-?Oxo-?4-?phenyl-?3-?pyrrolidinecarboxyli?c acid 2-?[1-? (3-?bromophenyl) ?ethylidene]?hydrazide
Available Sizes
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