RK-33
RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3-overexpressing cells. Overall, inhibition of DDX3 by RK-33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.
Product Specifications
CAS Number
1070773-09-9
Product Name Alternative
RK-33 | RK 33 | RK33.
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (116.70 mM)
Smiles
COC1=CC=C (C=C1) CN2C=NC3=C2N=CN=C4C3=NC (=O) N4CC5=CC=C (C=C5) OC
Molecular Formula
C23H20N6O3
Molecular Weight
428.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3,7-dihydro-3,7-bis[ (4-methoxyphenyl) methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one
Available Sizes
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