MLN2480
TAK-580, also known as MLN2480, BIIB024, and AMG 2112819, is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.
Product Specifications
CAS Number
1096708-71-2
Product Name Alternative
TAK-580, TAK 580, TAK580, MLN 2480, MLN-2480, MLN2480
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL 98.76 mM
Smiles
Nc1ncnc (C (=O) N[C@H] (C) c2ncc (C (=O) Nc3ncc (Cl) c (C (F) (F) F) c3) s2) c1Cl
Molecular Formula
C17H12Cl2F3N7O2S
Molecular Weight
506.29
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(R) -2- (1- (6-amino-5-chloropyrimidine-4-carboxamido) ethyl) -N- (5-chloro-4- (trifluoromethyl) pyridin-2-yl) thiazole-5-carboxamide
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