MD2-IN-1
MDK7229, also known as MD2-IN-1 is a MD2 (Myeloid differentiation protein 2) inhibitor. MDK7229 has CAS#111797-22-9. For easy communication, we use its last 4 digit of CAS for name. MDK7229 locked the LPS-induced activation of TLR4/MD2 -downstream pro-inflammatory MAPKs/NF-κB signaling pathways. In a rat model with ALI induced by intracheal LPS instillation, administration MDK7229 exhibited significant protective effect against ALI, accompanied by the inhibition of TLR4/MD2 complex formation in lung tissues.
Product Specifications
CAS Number
111797-22-9
Product Name Alternative
MD2-IN-1 | MDK7229 | MDK 7229 | MDK 7229.
Field of Research
Immunology & Inflammation
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL 139.51 mM; H2O : < 0.1 mg/mL
Smiles
COc1ccc (cc1OC) C (=O) \C=C\c1cc (OC) c (OC) c (OC) c1
Molecular Formula
C20H22O6
Molecular Weight
358.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -1- (3,4-dimethoxyphenyl) -3- (3,4,5-trimethoxyphenyl) prop-2-en-1-one
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