Sal003
SAL-003 is a cell-permeable inhibitor of eIF2α dephosphorylation. SAL003 is an Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Sal003 mediated upregulation of eIF2α phosphorylation suppressed cisplatin induced p53 activation. Furthermore, reduction of eIF2α phosphorylation by PERK knockdown enhanced cisplatin-induced p53 activation and apoptosis.
Product Specifications
CAS Number
1164470-53-4
Product Name Alternative
SAL-003 | SAL 003 | SAL003
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL 215.88 mM
Smiles
C1ccc (cc1) /C=C/C (=O) NC (C (Cl) (Cl) Cl) NC (=S) Nc1ccc (cc1) Cl
Molecular Formula
C18H15Cl4N3OS
Molecular Weight
463.21
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3--Phenyl-N- (2,2,2-trichloro-1- ((((4-chlorophenyl) amino) carbonothioyl) amino) ethyl) acrylamide
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