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YU238259

YU238259 is a selective small molecule inhibitor of homology-directed repair (HDR) that spares non-homologous end joining (NHEJ), as demonstrated in cellular GFP reporter assays. This tool compound is useful for studying DNA repair pathway choice, synthetic lethality, and radiosensitization in both in vitro and in vivo cancer research models.

Product Specifications

CAS Number

1943733-16-1

Product Name Alternative

Inhibitor, inhibit, HDR, DNAPK, DNA-PK, DNA-dependent protein kinase, YU 238259, YU238259, YU-238259

Field of Research

Molecular Biology, Signal Transduction

Purity

99.12% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:84 mg/mL (182.63 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (7.17 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Smiles

COc1ccc (cc1) S (=O) (=O) NCc1ccc (cc1) C (=O) NCCc1ccc (Cl) cn1

Molecular Formula

C22H22ClN3O4S

Molecular Weight

459.95

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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