YU238259
YU238259 is a selective small molecule inhibitor of homology-directed repair (HDR) that spares non-homologous end joining (NHEJ), as demonstrated in cellular GFP reporter assays. This tool compound is useful for studying DNA repair pathway choice, synthetic lethality, and radiosensitization in both in vitro and in vivo cancer research models.
Product Specifications
CAS Number
1943733-16-1
Product Name Alternative
Inhibitor, inhibit, HDR, DNAPK, DNA-PK, DNA-dependent protein kinase, YU 238259, YU238259, YU-238259
Field of Research
Molecular Biology, Signal Transduction
Purity
99.12% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:84 mg/mL (182.63 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (7.17 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
COc1ccc (cc1) S (=O) (=O) NCc1ccc (cc1) C (=O) NCCc1ccc (Cl) cn1
Molecular Formula
C22H22ClN3O4S
Molecular Weight
459.95
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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