UK-5099
UK-5099 (PF-1005023) is a cell-permeable inhibitor that selectively and reversibly targets the mitochondrial pyruvate carrier (MPC) at the MPC2 subunit, blocking pyruvate import into mitochondria. Its ability to modulate pyruvate metabolism has established its utility as a research tool in oncology, with demonstrated antitumor effects in both cellular and animal models of cancer.
Product Specifications
CAS Number
56396-35-1
Product Name Alternative
MPC, inhibit, Mitochondrial Metabolism, MitochondrialMetabolism, Inhibitor, UK5099, UK-5099, UK 5099, PF 1005023, PF1005023, PF-1005023
Field of Research
Cancer Biology, Neuroscience, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Mitochondrial pyruvate carrier inhibitor; cell impermeable
Form
Powder
Solubility
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml)
Smiles
OC (=O) C (=Cc1cn (-c2ccccc2) c2ccccc12) C#N
Molecular Formula
C18H12N2O2
Molecular Weight
288.30
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-Cyano-3- (1-phenyl-1H-indol-3-yl) -2-propenoic acid
Available Sizes
Frequently Asked Questions
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