Cilomilast
Cilomilast (SB-207499) is a selective PDE4 inhibitor with an IC50 of approximately 110 nM, exhibiting potent anti-inflammatory effects with minimal CNS penetration. It has been investigated in clinical Phase 3 trials for chronic obstructive pulmonary disease (COPD) and studied in models of inflammatory cell activation.
Product Specifications
CAS Number
153259-65-5
Product Name Alternative
COPD, chronic, Cilomilast, disease, anti-inflammatory, Ariflo, asthma, HPDE4, obstructive, LPDE4, PDE4, immunomodulatory, Inhibitor, inhibit, phosphodiesterase, Phosphodiesterase, Phosphodiesterase (PDE), SB 207499, SB207499, SB-207499, pulmonary
Field of Research
Metabolism Research
Purity
97.37% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:60 mg/mL (174.71 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.82 mM) ; Ethanol:31 mg/mL (90.27 mM)
Smiles
COc1ccc (cc1OC1CCCC1) [C@]1 (CC[C@@H] (CC1) C (O) =O) C#N
Molecular Formula
C20H25NO4
Molecular Weight
343.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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