Vactosertib
Vactosertib (EW-7197) is an orally active, small-molecule inhibitor targeting the TGF-β receptor type I (ALK5) . It is widely used in cancer research to investigate TGF-β signaling pathways in both in vitro cellular assays and in vivo animal models for its potential antitumor effects.
Product Specifications
CAS Number
1352608-82-2
Product Name Alternative
Vactosertib, Transforming growth factor beta receptors, Smad, TEW 7197, TEW7197, TEW-7197, TGF-b/Smad, TGFbeta, TGFb, TGF-β Receptor, TGF-β/Smad, TGFβ, TGF-beta, TGFbeta/Smad, survival, p38α, Inhibitor, EW7197, EW-7197, EW 7197, inhibit, invasion, migration, antimetastatic, cancer, ALK5, ALK3, ALK4, ALK2, ALK1, breast, cell
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.85% (May vary between batches)
Solubility
DMSO:252.5 mg/mL (632.17 mM) ; Ethanol:40 mg/mL (100.15 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cc1cccc (n1) -c1[nH]c (CNc2ccccc2F) nc1-c1ccc2ncnn2c1
Molecular Formula
C22H18FN7
Molecular Weight
399.42
Storage Conditions
-20°C
Notes
For research use only.
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