Galeterone
Galeterone (VN 124) is an orally active small molecule that antagonizes the androgen receptor, inhibits CYP17A1 lyase activity, and reduces androgen receptor protein levels, thereby suppressing androgen signaling in prostate cancer. It is used in research for studying castration-resistant prostate cancer mechanisms and has been evaluated in both in vitro assays and in vivo xenograft models.
Product Specifications
CAS Number
851983-85-2
Product Name Alternative
Inhibitor, Galeterone, inhibit, AndrogenReceptor, Androgen Receptor, CYPs, CYP17, Cytochrome P450, TOK 001, TOK001, TOK-001, VN 124, VN/124-1, VN124, VN-124, VN-124-1
Field of Research
Metabolism Research
Purity
99.47% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.15 mM) ; DMSO:19.4 mg/mL (49.93 mM) ; Ethanol:19.4 mg/mL (49.93 mM)
Smiles
C[C@]12CC[C@H]3[C@@H] (CC=C4C[C@@H] (O) CC[C@]34C) [C@@H]1CC=C2n1cnc2ccccc12
Molecular Formula
C26H32N2O
Molecular Weight
388.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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