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KU-0060648

KU-0060648 is a potent small molecule inhibitor that primarily targets DNA-PK and the PI3Kα, β, and δ isoforms with low nanomolar IC50 values, while showing significantly weaker activity against PI3Kγ. This profile makes it a useful research tool for investigating DNA damage response and PI3K signaling pathways in both cellular and animal models of cancer and other diseases.

Product Specifications

CAS Number

881375-00-4

Product Name Alternative

KU0060648, KU-0060648, KU 0060648, inhibit, mTOR, Inhibitor, Mammalian target of Rapamycin, DNA-dependent protein kinase, DNAPK, DNA-PK, PI3K, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, Phosphoinositide 3-kinase

Field of Research

Molecular Biology, Signal Transduction

Purity

98.75% (May vary between batches)

Smiles

CCN1CCN (CC (=O) Nc2ccc (-c3cccc4c3oc (cc4=O) N3CCOCC3) c3sc4ccccc4c23) CC1

Molecular Formula

C33H34N4O4S

Molecular Weight

582.71

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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