NU6027
NU6027 is a cell-permeable small molecule inhibitor targeting key DNA damage response kinases, with Ki values of 0.4 μM for ATR, 2.5 μM/1.3 μM for CDK1/2, and 2.2 μM for DNA-PK. It is a valuable research tool for studying cell cycle checkpoints and DNA repair mechanisms in both in vitro and in vivo cancer models.
Product Specifications
CAS Number
220036-08-8
Product Name Alternative
DNAPK, DNA-PK, Cyclin dependent kinase, cytotoxicity, CDK1, CDK, CDK2, cisplatin, cancer, Ataxia telangiectasia mutated, ATM, ATM/ATR, ATM and RAD3 related, ATR, NU 6027, NU6027, NU-6027, inhibit, Inhibitor, hydroxyurea
Field of Research
Cell Biology, Molecular Biology, Signal Transduction
Purity
98.36% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.98 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:3 mg/mL (11.94 mM) ; DMSO:5.5 mg/mL (21.89 mM)
Smiles
Nc1nc (N) c (N=O) c (OCC2CCCCC2) n1
Molecular Formula
C11H17N5O2
Molecular Weight
251.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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