4'-Demethylpodophyllotoxin

4'-Demethylpodophyllotoxin is an aryltetralin lignin contained in the root of Podophyllum hexandrum and P. peltatum. 4'-Demethylpodophyllotoxin exhibits cytotoxic potential in diverse cancer cell lines[1][2].

Product Specifications

CAS Number

[40505-27-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-demethylpodophyllotoxin.html

Purity

99.77

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1[C@]2([H])[C@H](C3=CC(OC)=C(O)C(OC)=C3)C(C=C(OCO4)C4=C5)=C5[C@H](O)[C@@]2([H])CO1

Molecular Formula

C21H20O8

Molecular Weight

400.38

Precautions

H315, H319, H335

References & Citations

[1]David E.Jackson, et al. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry, 1984, 23 (5) : 1147-1152.|[2]Zilla MK, et al. 4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells. Chem Biol Interact. 2014 Dec 5;224:100-7.