TCS-PIM-1-4a
TCS-PIM-1-4a (SMI-4a) is a potent Pim kinase inhibitor that exhibits broad anti-leukemic activity. It induces cell death in diverse myeloid and lymphoid lines (IC50 0.8-40 μM) by activating AMPK to suppress mTORC1 signaling. This mechanism supports its use in vitro for studying hematological malignancies and related pathway interactions.
Product Specifications
CAS Number
327033-36-3
Product Name Alternative
Cell-cycle, Bax, Bak, Apoptosis, arrest, 4E-BP1, mTORC1, inhibit, Inhibitor, Leukemic, SMI-4a, TCSPIM14a, TCS-PIM-1-4a, TCS PIM 1 4a, Pim kinases, Pim1, Pim2, Pim, p27Kip1
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
98.82% (May vary between batches)
Solubility
DMSO:55 mg/mL (201.3 mM)
Smiles
C (=C1SC (=O) NC1=O) C2=CC (C (F) (F) F) =CC=C2
Molecular Formula
C11H6F3NO2S
Molecular Weight
273.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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