TCS-PIM-1-4a
TCS-PIM-1-4a (SMI-4a) is a potent Pim kinase inhibitor that exhibits broad anti-leukemic activity. It induces cell death in diverse myeloid and lymphoid lines (IC50 0.8-40 μM) by activating AMPK to suppress mTORC1 signaling. This mechanism supports its use in vitro for studying hematological malignancies and related pathway interactions.
Product Specifications
CAS Number
327033-36-3
Product Name Alternative
Cell-cycle, Bax, Bak, Apoptosis, arrest, 4E-BP1, mTORC1, inhibit, Inhibitor, Leukemic, SMI-4a, TCSPIM14a, TCS-PIM-1-4a, TCS PIM 1 4a, Pim kinases, Pim1, Pim2, Pim, p27Kip1
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
98.82% (May vary between batches)
Solubility
DMSO:55 mg/mL (201.3 mM)
Smiles
C (=C1SC (=O) NC1=O) C2=CC (C (F) (F) F) =CC=C2
Molecular Formula
C11H6F3NO2S
Molecular Weight
273.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS9371943 Inquire
Plant Lipolysaccharide Binding Protein (LBP) ELISA Kit
Sign In for Pricing
View Details 
T8666-14C-HRP 100 µL
TRPC3 (NT) (Transient Receptor Potential Cation Channel, Subfamily C, Member 3, HTRP-3, HTRP3, TRP3) (HRP) discontinued
Sign In for Pricing
View Details 
MBS1078230-01 0.02 mg (E-Coli)
Recombinant Proteus vulgaris HTH-type transcriptional regulator BlaA (blaA)
Sign In for Pricing
View Details MBS1078230-02 0.02 mg (Yeast)
Recombinant Proteus vulgaris HTH-type transcriptional regulator BlaA (blaA)
Sign In for Pricing
View Details MBS1078230-03 0.1 mg (E-Coli)
Recombinant Proteus vulgaris HTH-type transcriptional regulator BlaA (blaA)
Sign In for Pricing
View Details MBS1078230-04 0.1 mg (Yeast)
Recombinant Proteus vulgaris HTH-type transcriptional regulator BlaA (blaA)
Sign In for Pricing
View Details