Larotrectinib
Larotrectinib (LOXO-101) is a highly selective, orally bioavailable small molecule inhibitor targeting the TRK family of kinases with low nanomolar potency (IC50 2-20 nM) . It is widely used in preclinical research to investigate TRK-driven cancers, supporting both in vitro cellular assays and in vivo tumor model studies.
Product Specifications
CAS Number
1223403-58-4
Product Name Alternative
LOXO-101; ARRY-470
Field of Research
Neuroscience
Purity
>98%
Bioactivity
TRK inhibitor (pan)
Form
Powder
Solubility
Soluble in DMSO (up to 5 mg/ml)
Smiles
O[C@H]1CCN (C1) C (=O) Nc1cnn2ccc (nc12) N1CCC[C@@H]1c1cc (F) ccc1F
Molecular Formula
C21H22F2N6O2
Molecular Weight
428.44
Storage Conditions
RT
Notes
For research use only.
Other Product Names
(3S) -N-[5-[ (2R) -2- (2,5-Difluorophenyl) pyrrolidine-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide
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