PF429242 (dihydrochloride)
PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1].
Product Specifications
CAS Number
2248666-66-0
UNSPSC
12352005
Hazard Statement
H302, H319, H372, H410
Target
Fatty Acid Synthase (FASN) ; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/PF429242_dihydrochloride.html
Purity
99.80
Solubility
DMSO : ≥ 83.3 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N(CCC1=CC=CC=C1OC)[C@H]2CNCC2)C3=CC=C(CN(CC)CC)C=C3.[H]Cl.[H]Cl
Molecular Formula
C25H37Cl2N3O2
Molecular Weight
482.49
Precautions
H302, H319, H372, H410
References & Citations
[1]Hawkins JL, et al. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol Exp Ther. 2008 Sep;326 (3) :801-8.|[2]Uchida L, et al. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses. 2016 Feb 10;8 (2) . pii: E46. doi: 10.3390/v8020046.|[3]Urata S, et al. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol. 2011 Jan;85 (2) :795-803.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Autophagy. 2021 Jul;17 (7) :1592-1613.|Cell Death Differ. 2021 Jun;28 (6) :2001-2018.|Cell Death Dis. 2025 Jul 11;16 (1) :512.|Hypertension. 2021 Feb;77 (2) :405-416.|Immunity. 2018 Nov 20;49 (5) :842-856.e7. |JCI Insight. 2019 Apr 4;4 (7) . pii: 124174. |Nature. 2023 Apr;616 (7956) :348-356.|Sci China Life Sci. 2022 Feb;65 (2) :341-361.|J Neurosci Res. 2025 Jun;103 (6) :e70054.
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