PF429242 (dihydrochloride)

PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1].

Product Specifications

CAS Number

[2248666-66-0]

UNSPSC

12352005

Hazard Statement

H302, H319, H372, H410

Target

Fatty Acid Synthase (FASN) ; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/PF429242_dihydrochloride.html

Purity

99.80

Solubility

DMSO : ≥ 83.3 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(N(CCC1=CC=CC=C1OC)[C@H]2CNCC2)C3=CC=C(CN(CC)CC)C=C3.[H]Cl.[H]Cl

Molecular Formula

C25H37Cl2N3O2

Molecular Weight

482.49

Precautions

H302, H319, H372, H410

References & Citations

[1]Hawkins JL, et al. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol Exp Ther. 2008 Sep;326 (3) :801-8.|[2]Uchida L, et al. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses. 2016 Feb 10;8 (2) . pii: E46. doi: 10.3390/v8020046.|[3]Urata S, et al. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol. 2011 Jan;85 (2) :795-803.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Autophagy. 2021 Jul;17 (7) :1592-1613.|Cell Death Differ. 2021 Jun;28 (6) :2001-2018.|Cell Death Dis. 2025 Jul 11;16 (1) :512.|Hypertension. 2021 Feb;77 (2) :405-416.|Immunity. 2018 Nov 20;49 (5) :842-856.e7. |JCI Insight. 2019 Apr 4;4 (7) . pii: 124174. |Nature. 2023 Apr;616 (7956) :348-356.|Sci China Life Sci. 2022 Feb;65 (2) :341-361.|J Neurosci Res. 2025 Jun;103 (6) :e70054.