SR-1001
SR 1001 is a potent inverse agonist targeting the nuclear receptors RORα and RORγ, with inhibitory constants (Kis) of 172 nM and 111 nM, respectively. It is a valuable chemical probe for studying Th17 cell biology, autoimmune mechanisms, and inflammatory diseases in both cellular and animal models.
Product Specifications
CAS Number
1335106-03-0
Product Name Alternative
Inhibitor, inhibit, RAR-related orphan receptor, ROR, RORα, RORγ, SR 1001, SR1001, SR-1001
Field of Research
Cardiovascular Research, Cell Biology, Immunology & Inflammation
Purity
>98%
Bioactivity
RORag agonist
Form
Powder
Solubility
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml) .
Smiles
CC (=O) Nc1nc (C) c (s1) S (=O) (=O) Nc1ccc (cc1) C (O) (C (F) (F) F) C (F) (F) F
Molecular Formula
C15H13F6N6O4S2
Molecular Weight
477.39
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N- (5- (N- (4- (1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl) phenyl) sulphamoyl) -4-methylthiazol-2-yl) acetamide
Available Sizes
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