COH000
COH000 is an irreversible covalent inhibitor of the SUMO-activating enzyme, effectively blocking SUMOylation with an in vitro IC50 of approximately 0.2 μM. This compound is a valuable research tool for investigating SUMOylation's role in cellular processes such as stress response, cell cycle regulation, and DNA repair in both cellular and animal models.
Product Specifications
CAS Number
1534358-79-6
Product Name Alternative
Ubiquitin-activating Enzyme E1, Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme, Inhibitor, inhibit, E1 activating enzyme, E1/E2/E3 Enzyme, E1 Enzyme, E1Enzyme, E2 conjugating enzyme, E2 Enzyme, E3 ligating enzyme, E3Enzyme, E2Enzyme, E3 Enzyme, COH 000, COH000, COH-000
Field of Research
Protein Biochemistry
Purity
96.91% (May vary between batches)
Solubility
H2O:< 0.1 mg/mL (insoluble) ; DMSO:35.71 mg/mL (85.13 mM)
Smiles
[H][C@]12O[C@@] (C=C1) ([C@@H] (Cc1ccc (C) cc1) Nc1ccccc1) C (C (=O) OC) =C2C (=O) OC
Molecular Formula
C25H25NO5
Molecular Weight
419.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
19309114 3x 1.0 µg
Enpp2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
Sign In for Pricing
View Details 
LV745100 1.0 µg DNA
RN5S386 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
Sign In for Pricing
View Details 