IACS-010759
IACS-010759 is an orally active small molecule inhibitor targeting mitochondrial complex I (NADH:ubiquinone oxidoreductase) . It disrupts oxidative phosphorylation and is utilized in both in vitro and in vivo research to study cancer metabolism, particularly in models reliant on oxidative phosphorylation for growth.
Product Specifications
CAS Number
1570496-34-2
Product Name Alternative
H460, Inhibitor, IACS 010759, IACS 10759, IACS010759, IACS-010759, IACS10759, IACS-10759, orally, oxidative, OXPHOS, mitochondrial, Mitochondrial Metabolism, MitochondrialMetabolism, inhibit, Apoptosis, AML, complex, complex I of oxidative phosphorylation, phosphorylation
Field of Research
Cell Biology, Metabolism Research
Purity
>98%
Form
Powder
Solubility
Soluble in DMSO (25 mg/ml)
Smiles
Cc1nc (nn1Cc1cccc (c1) N1CCC (CC1) S (C) (=O) =O) -c1nc (no1) -c1ccc (OC (F) (F) F) cc1
Molecular Formula
C25H25F3N6O4S
Molecular Weight
562.6
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
5-[5-Methyl-1-[[3- (4-methylsulfonylpiperidin-1-yl) phenyl]methyl]-1,2,4-triazol-3-yl]-3-[4- (trifluoromethoxyphenyl]-1,2,4-oxadiazole
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