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AZD3839 free base

AZD3839 free base is a potent and selective BACE1 inhibitor (Ki = 26.1 nM) with 14-fold selectivity versus BACE2. This compound has been evaluated in Phase 1 clinical trials and serves as a research tool for Alzheimer's disease studies in biochemical and cellular assays.

Product Specifications

CAS Number

1227163-84-9

Product Name Alternative

βSecretase, β-Secretase, BetaSecretase, Beta-secretase, b-Secretase, bSecretase, BACE, AZD3839, AZD-3839, AZD3839 free base, AZD-3839 free base, AZD 3839

Field of Research

Neuroscience

Purity

99.93% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.65 mM) ; DMSO:80 mg/mL (185.44 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:80 mg/mL (185.44 mM)

Smiles

NC1=N[C@@] (c2cccc (F) c12) (c1cccc (c1) -c1cncnc1) c1ccnc (c1) C (F) F

Molecular Formula

C24H16F3N5

Molecular Weight

431.41

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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