Uprosertib
Uprosertib (GSK2141795) is a broad-spectrum, ATP-competitive Akt inhibitor with IC50 values of 180, 328, and 38 nM for Akt1, Akt2, and Akt3, respectively. It is a research tool used in vitro and in vivo to study PI3K/Akt pathway signaling in oncology and metabolic disease research.
Product Specifications
CAS Number
1047634-65-0
Product Name Alternative
Inhibit, GSK795, GSK-795, GSK 2141795, GSK 795, GSK2141795, GSK-2141795, Inhibitor, Akt, Akt3, Akt2, Akt1, Protein kinase B, PKB, Uprosertib
Field of Research
Signal Transduction
Purity
95.10% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.66 mM) ; Ethanol:76 mg/mL (177.05 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:65 mg/mL (151.43 mM)
Smiles
Cn1ncc (Cl) c1-c1cc (oc1Cl) C (=O) NC (CN) Cc1ccc (F) c (F) c1
Molecular Formula
C18H16Cl2F2N4O2
Molecular Weight
429.25
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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