PI-1840

PI-1840 is a potent, reversible, and selective inhibitor of the proteasome's chymotrypsin-like (CT-L) activity (IC50 = 27 nM), exhibiting minimal effect on trypsin-like and postglutamyl-peptide-hydrolysis-like activities. This compound is a valuable research tool for studying proteasome function in cellular models and has been utilized in investigations of cancer and neurodegenerative disease pathways.

Product Specifications

CAS Number

1401223-22-0

Product Name Alternative

Cell proliferation, cell cycle, Chymotrypsin-like proteasome, Bcl-2 Family, Caspase, Autophagy, anticancer, Apoptosis, Inhibitor, inhibit, MG-63 cells, PARP, Nuclear factor-kappaB, Nuclear factor-κB, NF-κB, poly ADP ribose polymerase, PI1840, PI-1840, PI 1840, Proteasome, proteasome substrates, U2-OS cells

Field of Research

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction

Purity

98.82% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.07 mM) ; Ethanol:31 mg/mL (78.59 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:72 mg/mL (182.52 mM)