HDAC8-IN-1

MDK-7933 (HDAC8-IN-1) is a potent and selective HDAC8 inhibitor (IC50 = 27.2 nM) . It demonstrates antiproliferative and cytotoxic activity against human lung cancer cell lines, including A549, H1299, and CL1-5, while showing minimal effects on normal IMR-90 cells. This compound is a valuable research tool for studying HDAC8 biology in oncology and cancer cell signaling pathways.