Tuxobertinib
Tuxobertinib (BDTX-189) is a highly selective, allosteric inhibitor targeting oncogenic mutations in EGFR and HER2, demonstrating potent anticancer activity. It has shown efficacy in preclinical in vitro and in vivo models for non-small cell lung cancer and other solid tumors driven by these mutations.
Product Specifications
CAS Number
2414572-47-5
Product Name Alternative
Ba/F3, BLK, BDTX 189, BDTX189, BDTX-189, allosteric, mice, oral, oncogene athymic, nude, inhibit, mutants, HER1, HER2, Inhibitor, insertion, EGFR, Epidermal growth factor receptor, ErbB-1, RIP kinase, RIPK2, RIPkinase, Tuxobertinib
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
98.86% (May vary between batches)
Solubility
DMSO:41.67 mg/mL (74.27 mM)
Smiles
Clc1cc (Nc2ncnc3cc (OCCN4CCOCC4) c (NC (=O) C=C) cc23) ccc1OCc1ccccn1
Molecular Formula
C29H29ClN6O4
Molecular Weight
561.03
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
ELI-49936h 96 Tests
Human T-cell surface glycoprotein CD1c, CD1C ELISA KIT
Sign In for Pricing
View Details K6229904 1.0 µg DNA
Krtap1-5 sgRNA CRISPR Lentivector (Rat) (Target 3)
Sign In for Pricing
View Details 
MBS2077428-01 0.1 mL
FITC-Linked Polyclonal Antibody to Spectrin Beta, Non Erythrocytic 4 (SPTbN4)
Sign In for Pricing
View Details MBS2077428-02 0.2 mL
FITC-Linked Polyclonal Antibody to Spectrin Beta, Non Erythrocytic 4 (SPTbN4)
Sign In for Pricing
View Details MBS2077428-03 0.5 mL
FITC-Linked Polyclonal Antibody to Spectrin Beta, Non Erythrocytic 4 (SPTbN4)
Sign In for Pricing
View Details