Topovale
Topovale (ARC111) is a potent topoisomerase I inhibitor that suppresses hypoxia-induced HIF-1α accumulation. It demonstrates low nanomolar cytotoxicity against various cancer cell lines, with activity shown to be dependent on functional topoisomerase I in comparative in vitro studies using sensitive and resistant cell models.
Product Specifications
CAS Number
500214-53-9
Product Name Alternative
ARC111, ARC-111, ARC 111, topoisomerase I, Topoval, Topovale
Field of Research
Molecular Biology
Purity
99.94% (May vary between batches)
Solubility
DMSO:Insoluble
Smiles
C (CN (C) C) N1C2=C (C=3C (C1=O) =CC (OC) =C (OC) C3) C=NC=4C2=CC5=C (C4) OCO5
Molecular Formula
C23H23N3O5
Molecular Weight
421.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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