Upadacitinib
Upadacitinib (ABT-494) is a potent and selective JAK1 inhibitor with an IC50 of 43 nM. It is widely used in research for autoimmune diseases, demonstrating efficacy in both in vitro assays and in vivo models of rheumatoid arthritis and inflammatory bowel disease.
Product Specifications
CAS Number
1310726-60-3
Product Name Alternative
ABT494, ABT-494, ABT 494, autoimmune, Inhibitor, JAK2, JAK1, JAK, inhibit, Janus kinase, orally active, Upadacitinib
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.96% (May vary between batches)
Solubility
DMSO:55 mg/mL (144.6 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.63 mM)
Smiles
CC[C@@H]1CN (C[C@@H]1c1cnc2cnc3[nH]ccc3n12) C (=O) NCC (F) (F) F
Molecular Formula
C17H19F3N6O
Molecular Weight
380.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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