Exatecan Mesylate

Exatecan Mesylate (DX-8951f) is a potent inhibitor of DNA topoisomerase I, exhibiting an IC50 of 2.2 μM. This camptothecin analog has demonstrated antitumor activity in both in vitro cytotoxicity assays and in vivo xenograft models, supporting its research use in oncology and cancer pharmacology.

Product Specifications

CAS Number

169869-90-3

Product Name Alternative

DX8951f, ADC Cytotoxin, ADCCytotoxin, Exatecan, Exatecan Mesylate, Inhibitor, inhibit, Topoisomerase, Topo I

Field of Research

Molecular Biology, Pharmacology & Drug Discovery

Purity

97.32% (May vary between batches)

Solubility

H2O:6 mg/mL (11.29 mM) ; DMSO:8 mg/mL (15.05 mM)

Smiles

CS (O) (=O) =O.CC[C@@]1 (O) C (=O) OCc2c1cc1-c3nc4cc (F) c (C) c5CC[C@H] (N) c (c3Cn1c2=O) c45

Molecular Formula

C25H26FN3O7S

Molecular Weight

531.55

Storage Conditions

Keep away from direct sunlight, store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.