NF-κB-IN-1
NF-κB-IN-1 is a synthetic 4-arylidene curcumin analog that acts as a potent inhibitor of the NF-κB signaling pathway by directly targeting IKK. This compound has demonstrated efficacy in vitro by reducing the viability and clonogenic growth of lung cancer cells such as A549.
Product Specifications
CAS Number
1227098-15-8
Product Name Alternative
Crucumin, A549, 4-arylidene, 1,6-Heptadiene-3,5-dione, 1,7-bis (3,4-dimethoxyphenyl) -4-[ (4-hydroxy-3-methoxyphenyl) methylene]-, (1E,6E) -, cancer, I kappa B kinase, IκB kinase, IκB, inhibit, IkB, IkB/IKK, IKK, Inhibitor, NFκBIN1, NF-κB-IN-1, NF-κB, NFκB, NF-kB-IN-1, NFkB, NF-kB, NF κB IN 1, NF-kappaB-IN-1, pathway, signaling
Field of Research
Signal Transduction
Purity
99.03% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.77 mM) ; DMSO:40 mg/mL (75.39 mM)
Smiles
COc1ccc (\C=C\C (=O) C (=Cc2ccc (O) c (OC) c2) C (=O) \C=C\c2ccc (OC) c (OC) c2) cc1OC
Molecular Formula
C31H30O8
Molecular Weight
530.57
Storage Conditions
-20°C
Notes
For research use only.
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