BSJ-4-116
BSJ-4-116 is a potent and selective CDK12-targeting PROTAC degrader with 6 nM IC50. It disrupts DNA damage response gene transcription via premature termination and increased polyadenylation, applicable for oncology research in both cellular and animal models to study transcription-dependent vulnerabilities.
Product Specifications
CAS Number
2519823-34-6
Product Name Alternative
Cereblon, CDK12, CDK, degrader, Cyclin dependent kinase, C1039F, cancer, BSJ4116, BSJ-4-116, BSJ 4 116, antiproliferative, Kelly, mutation, inhibit, Inhibitor, PROTACs
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
99.09% (May vary between batches)
Solubility
DMSO:250 mg/mL (298.55 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (5.97 mM)
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2OCC (NCCCCCCCN4C[C@H] (NC=5N=C (NC6=C (S (C (C) C) (=O) =O) C=CC=C6) C (Cl) =CN5) CCC4) =O
Molecular Formula
C40H49ClN8O8S
Molecular Weight
837.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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