MRTX1133
MRTX1133 is a potent, selective, and non-covalent small-molecule inhibitor targeting the KRAS G12D mutant with sub-picomolar affinity (K_D = 0.2 pM) . It demonstrates antitumor efficacy in G12D-mutated cell lines and in vivo models, showing selectivity over wild-type KRAS, making it a valuable research tool for oncology and targeted therapy studies.
Product Specifications
CAS Number
2621928-55-8
Product Name Alternative
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
96.84% (May vary between batches)
Solubility
DMSO: 50 mg/mL (83.25 mM), Sonication is recommended
Smiles
C (OC=1N=C (C2=C (N1) C (F) =C (N=C2) C=3C4=C (C=C (O) C3) C=CC (F) =C4C#C) N5CC6NC (C5) CC6) [C@@]78N (C[C@H] (F) C7) CCC8
Molecular Formula
C33H31F3N6O2
Molecular Weight
600.63
References & Citations
Elodie Roger et al. ATM Deficiency Induces TGF-β-Mediated Stromal Programming in Pancreatic Cancer Cancer Res, (2026)
Pubmed id
42113576
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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