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MRTX1133

MRTX1133 is a potent, selective, and non-covalent small-molecule inhibitor targeting the KRAS G12D mutant with sub-picomolar affinity (K_D = 0.2 pM) . It demonstrates antitumor efficacy in G12D-mutated cell lines and in vivo models, showing selectivity over wild-type KRAS, making it a valuable research tool for oncology and targeted therapy studies.

Product Specifications

CAS Number

2621928-55-8

Product Name Alternative

Active, cells, Inhibitor, ERK, G12D, mutant, MRTX1133, MRTX-1133, MRTX 1133, inactive, KRAS G12D, KRAS, inhibit, tumor, states, Ras, phosphorylation, wild-type

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Purity

96.84% (May vary between batches)

Solubility

DMSO: 50 mg/mL (83.25 mM), Sonication is recommended

Smiles

C (OC=1N=C (C2=C (N1) C (F) =C (N=C2) C=3C4=C (C=C (O) C3) C=CC (F) =C4C#C) N5CC6NC (C5) CC6) [C@@]78N (C[C@H] (F) C7) CCC8

Molecular Formula

C33H31F3N6O2

Molecular Weight

600.63

References & Citations

Elodie Roger et al. ATM Deficiency Induces TGF-β-Mediated Stromal Programming in Pancreatic Cancer Cancer Res, (2026)

Pubmed id

42113576

Storage Conditions

-20°C

Notes

For research use only.

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