Apcin
Apcin is a potent, competitive inhibitor of the APC/C-Cdc20 E3 ligase, binding Cdc20 to block substrate recognition and ubiquitination. This inhibition arrests cells in mitosis and is synergistically enhanced by Ts-Arg-OMe, making it a valuable tool for studying cell cycle regulation, mitotic exit, and aneuploidy in both cellular and biochemical assays.
Product Specifications
CAS Number
300815-04-7
Product Name Alternative
Mitosis, inhibit, ligase, Inhibitor, cyclosome, complex, Cdc20, Apcin, APC/C, APC, anaphase-promoting, Anaphase promoting complex, pocket, recognition, WD40-domain, ubiquitylation
Field of Research
Cell Biology
Purity
96.48% (May vary between batches)
Solubility
DMSO:235 mg/mL (535.73 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.4 mM)
Smiles
Cc1ncc (n1CCC (=O) NC (Nc1ccccc1) C (Cl) (Cl) Cl) [N+] ([O-]) =O
Molecular Formula
C13H14Cl3N7O4
Molecular Weight
438.65
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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