CX-6258
A potent, selective, and orally efficacious pan-Pim inhibitor with IC50 of 5/25/16 nM for Pim1/2/3, respectively; exhibits in vitro synergy with chemotherapeutics and robust in vivo efficacy in driven tumor models; also decreases steady state levels and half-life of NKX3.1 protein but not mRNA in prostate cancer cells.Blood Cancer Discontinued.
Product Specifications
CAS Number
1202916-90-2
Product Name Alternative
CX6258 | CX 6258
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CN1CCCN (CC1) C (=O) C2=CC=CC (=C2) C3=CC=C (O3) /C=C/4\C5=C (C=CC (=C5) Cl) NC4=O
Molecular Formula
C26H24ClN3O3
Molecular Weight
461.9401
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Indol-2-one, 5-chloro-3-[[5-[3-[ (hexahydro-4-methyl-1H-1,4-diazepin-1-yl) carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-, (3E) -
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