P-50429
P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM) /USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs; exhibits 20-fold more potent inhibition of USP7 compared with P22077 (IC50 0.42 versus 8.0 uM) ; destabilizes HDM2, increases p53 and the downstream target p21, inhibits the proliferation of HCT-116 cells.
Product Specifications
CAS Number
1247825-37-1
Product Name Alternative
P50429 | P 50429
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 44 mg/mL
Smiles
O/C (C1=CC (C#N) =C (SC2=C (Cl) C=NC=C2Cl) S1) =N\C3=CC=C (S (=O) (C) =O) C=C3
Molecular Formula
C18H11Cl2N3O3S3
Molecular Weight
484.3992
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Thiophenecarboxamide, 4-cyano-5-[ (3,5-dichloro-4-pyridinyl) thio]-N-[4- (methylsulfonyl) phenyl]-
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