S49076 hydrochloride
S49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2; only inhibits 6% of kinases on a panel of 442 human wild-type and mutated kinases at 100 nM; inhibits the proliferation of MET- and FGFR2-dependent gastric cancer cells, blocks MET-driven migration of lung carcinoma cells, and inhibits colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL; causes tumor growth arrest in bevacizumab-resistant tumors in cancer xenograft models.Brain Cancer Phase 2 Clinical.
Product Specifications
CAS Number
1265966-31-1
Product Name Alternative
S 49076 | S-49076
Purity
>98% (HPLC)
Solubility
DMSO: Soluble (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
C1COCCN1CC2=CNC (=C2) C=C3C4=C (C=CC (=C4) CN5C (=O) CSC5=O) NC3=O.Cl
Molecular Formula
C22H23ClN4O4S
Molecular Weight
474.96
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-[[2,3-dihydro-3-[[4- (4-morpholinylmethyl) -1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-2,4-thiazolidinedione hydrochloride
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