N-Ethylmaleimide

N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies. (In Vitro) :N-Ethylmaleimide (20 μM;30 min) inhibits Akt Ser-473, Akt Thr-308 , p70S6K, ribosomal protein S6, 4E-BP1, eIF4E, BAD and FKHR-L1 phosphorylation.N-Ethylmaleimide (20 μM;30 min) affects conversion of pro-caspase-3 in vascular smooth muscle cells.N-Ethylmaleimide (20 μM;6 h) promotes vascular smooth muscle cells apoptosis.N-Ethylmaleimide (20 μM;30 min) affects PP2A activity and ROS production in vascular smooth muscle cells. (In Vivo) :N-Ethylmaleimide (10 mg/kg; i.h.) promotes the prevalence situation of mice with acute gastric ulcers.