MK2-IN-1 hydrochloride
MK2-IN-1 is a potent, selecitve, non-ATP competitive MAPKAPK2 (MK2) inhibitor with IC50 of 0.11 uM; shows excellent kinase selectivity against a broad panel of 150 protein kinases at 10 μM with only on exception of CK1γ3 >50 % inhibition; inhibits pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion; also dose dependently inhibits IL1β-stimulated MMP13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures.
Product Specifications
CAS Number
1314118-94-9
Product Name Alternative
MK2 Inhibitor
Purity
>98% (HPLC)
Solubility
DMSO
Smiles
O=C (C1=CC=C (C2=CC=C (Cl) C=C2) O1) N (C3=CC=C (N4CCNCC4) C=C3) CC5=NC=CC=C5.[H]Cl
Molecular Formula
C27H26Cl2N4O2
Molecular Weight
509.4269
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Furancarboxamide, 5- (4-chlorophenyl) -N-[4- (1-piperazinyl) phenyl]-N- (2-pyridinylmethyl) -, hydrochloride (1:1)
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