Naloxegol oxalate
Naloxegol (NKTR-118 and AZ-13337019), is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. It was approved in 2014 in adult patients with chronic, non-Y pain. Chemically, naloxegol is a pegylated (polyethylene glycol-modified) derivative of α-naloxol. Specifically, the 5-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free hydroxyl group of a monomethoxy-terminated n=7 oligomer of PEG.
Product Specifications
CAS Number
1354744-91-4
Product Name Alternative
AZ 13337019 | NKTR-118
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:≥ 40 mg/mL
Smiles
COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@]2 ([C@H]3CC4=C5[C@]2 ([C@H]1OC5=C (C=C4) O) CCN3CC=C) O.C (=O) (C (=O) O) O
Molecular Formula
C36H55NO15
Molecular Weight
741.828
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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