YH239-EE
YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4; induces apoptosis in AML cells and patient samples, induces p53 and activates the apoptotic caspase 3/7 in MOLM-13 (wt-p53) cells.
Product Specifications
CAS Number
1364488-67-4
Product Name Alternative
YH 239-EE | YH 239 EE
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 55 mg/mL
Smiles
O=C (C (N1) =C (C (N (CC2=CC=C (Cl) C=C2) C=O) C (NC (C) (C) C) =O) C3=C1C=C (Cl) C=C3) OCC
Molecular Formula
C25H27Cl2N3O4
Molecular Weight
504.4056
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[ (4-chlorophenyl) methyl]formylamino]-2-[ (1,1-dimethylethyl) amino]-2-oxoethyl]-, ethyl ester
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