Ruboxistaurin hydrochloride
A potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively; displays >60-fold selectivity over PKCα, and other ATP dependent kinases (PKA, Calcium calmodulin, Caesin kinase and Src) ; ameliorates the glomerular filtration rate, albumin excretion rate, and retinal circulation in diabetic rats.Heart Failure Phase 2 Discontinued.
Product Specifications
CAS Number
169939-93-9
Product Name Alternative
LY333531 hydrochloride | LY-333531 hydrochloride
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 6.8 mg/mL (Need ultrasonic and warming)
Smiles
CN (C) CC1CCN2C=C (C3=CC=CC=C32) C4=C (C5=CN (CCO1) C6=CC=CC=C65) C (=O) NC4=O.Cl
Molecular Formula
C28H29ClN4O3
Molecular Weight
505.0079
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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