KG-501
A small-molecule antagonist of CREB-CBP interaction, inhibits the cAMP-dependent activation of cellular genes via CREB; disruptes phospho (Ser-133) CREB binding to CBP KIX domain with Ki of 90 uM, similar Ki for binding of phospho (Ser-133) CREB protein to p300; also interferes with the Myb-KIX interaction in vitro and inhibits Myb activity in vivo.
Product Specifications
CAS Number
18228-17-6
Product Name Alternative
Naphthol AS-E phosphate
Purity
>98% (HPLC)
Solubility
DMSO : 6 mg/mL 15.88 mM; H2O : < 0.1 mg/mL
Smiles
O=C (C1=C (OP (O) (O) =O) C=C2C=CC=CC2=C1) NC3=CC=C (Cl) C=C3
Molecular Formula
C17H13ClNO5P
Molecular Weight
377.72
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Naphthanilide, 4'-chloro-3-hydroxy-, phosphate (6CI,7CI)
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